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ea0044oc5.4 | Diabetes Mellitus and Metabolism | SFEBES2016

Two contrasting cases of spontaneous severe hypoglycaemia secondary to anti-insulin antibodies (Insulin Autoimmune Syndrome / Hirata disease)

Moorthy Myuri , Freudenthal Bernard , Church David , Kisalu Judith , Woolman Emma , Hale Amy , Beynon Huw , Karra Efthimia , Cohen Mark , Khoo Bernard

IAS is a very rare condition in which anti-insulin antibodies carry high concentrations of insulin in suspension in circulation. Hypoglycaemia occurs when insulin is released from the antibodies during fasting or post-prandially.We present two cases. Patient-A is a 52-year old Thai obese female, with acanthosis nigricans and a strong family history of T2DM. Patient-B is a 28 year-old normal- BMI Caucasian female with an unremarkable history. None of the ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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